Yamamoto S1, Furukawa Y2, Fukushima S3, Nitta O2
1Josai International University, Physical Therapy, Chiba, Japan, 2Tokyo Metropolitan University, Physical Therapy, Tokyo, Japan, 3Ukima Central Hospital, Cardiology, Tokyo, Japan
Background: The study hypothesized that initial cardiopulmonary response to exercise could be a useful predictor of aerobic threshold in patients with heart failure.
Purpose: This study evaluated the correlation between aerobic threshold and cardiopulmonary responses to exercise onset by comparing heart failure patients using preserved (≥50%; HFpEF) and reduced ( 40%; HFrEF) left ventricular ejection fractions.
Methods: Twenty-one males (mean age was 68.5 years; 12 HFpEF and mean age was 60.4 years; 9 HFrEF) underwent a progressive submaximal cardiopulmonary exercise test using a cycle ergometer. The aerobic threshold, time constant, and area under oxygen uptake curve for the first 4 min (V̇O2AUC) were determined. Mean ejection fraction were 65.7% on HFpEF group and 29.7% on HFrEF group.
Results: A significant difference was observed on ejection fraction and V̇O2AUC between HFrEF(10.3mL/kg) and HFpEF(8.4mL/kg) groups on independent t-test. There were no significant differences on age, body mass index, time constant, aerobic threshold, and peak oxygen consumption (V̇O2) between HFrEF and HFpEF groups.
Conclusion(s): The results suggested that V̇O2AUC measured from exercise onset through an initial 4-min period were related the cardiac diastolic function.
Implications: This study suggested that V̇O2AUC measured from exercise onset through an initial 4-min period could provide an easily and safely obtained predictor to assess aerobic capacity in people with reduced left ventricular ejection fractions.
Keywords: Preserved ejection fraction, cardiac diastolic function, left ventricular ejection fraction
Funding acknowledgements: Our deepest appreciation to all subjects in this study.
Purpose: This study evaluated the correlation between aerobic threshold and cardiopulmonary responses to exercise onset by comparing heart failure patients using preserved (≥50%; HFpEF) and reduced ( 40%; HFrEF) left ventricular ejection fractions.
Methods: Twenty-one males (mean age was 68.5 years; 12 HFpEF and mean age was 60.4 years; 9 HFrEF) underwent a progressive submaximal cardiopulmonary exercise test using a cycle ergometer. The aerobic threshold, time constant, and area under oxygen uptake curve for the first 4 min (V̇O2AUC) were determined. Mean ejection fraction were 65.7% on HFpEF group and 29.7% on HFrEF group.
Results: A significant difference was observed on ejection fraction and V̇O2AUC between HFrEF(10.3mL/kg) and HFpEF(8.4mL/kg) groups on independent t-test. There were no significant differences on age, body mass index, time constant, aerobic threshold, and peak oxygen consumption (V̇O2) between HFrEF and HFpEF groups.
Conclusion(s): The results suggested that V̇O2AUC measured from exercise onset through an initial 4-min period were related the cardiac diastolic function.
Implications: This study suggested that V̇O2AUC measured from exercise onset through an initial 4-min period could provide an easily and safely obtained predictor to assess aerobic capacity in people with reduced left ventricular ejection fractions.
Keywords: Preserved ejection fraction, cardiac diastolic function, left ventricular ejection fraction
Funding acknowledgements: Our deepest appreciation to all subjects in this study.
Topic: Cardiorespiratory
Ethics approval required: Yes
Institution: Ukima Central Hospital
Ethics committee: Ethics Committee of Ukima Central Hospital
Ethics number: H25-1
All authors, affiliations and abstracts have been published as submitted.
