This study aimed to investigate the association between the FI-LAB on admission and HRQoL at 3 and 12 months post-stroke in AIS patients.This study aimed to investigate the association between the FI-LAB on admission and HRQoL at 3 and 12 months post-stroke in AIS patients.
A total of 9,726 patients with AIS from the China National Stroke Registry III (CNSR-III) were included. The FI-LAB was constructed based on 23 laboratory tests and 4 vital signs (systolic blood pressure, diastolic blood pressure, heart rate, and body mass index) on admission. The patients were divided into 4 groups according to quartiles of FI-LAB scores: Q1 (≤0.07), Q2 (0.07-0.15), Q3 (0.15-0.22), and Q4 (≥0.22). HRQoL measurements include the 3-level EuroQol five dimensions (EQ-5D-3L) index and EuroQol visual analog scale (EQ-5D VAS) scores at 3 and 12 months post-stroke. Linear and logistic regression analyses were used to explore the relationship between FI-LAB and HRQoL.
After adjusting for all covariates, FI-LAB was significantly associated with EQ-5D-3L scores at 3 months (β=-0.184, P=0.007) and 12 months (β=-0.200, P=0.004) post-stroke. Compared to the lowest frailty group (Q1), the highest frailty group (Q4) had significantly lower EQ-5D-3L scores at 3 months (β=-0.054, P=0.005) and 12 months (β=-0.052, P=0.006). Additionally, FI-LAB was significantly associated with EQ-5D VAS scores at 12 months post-stroke (β=-9.891, P=0.049).
FI-LAB is significantly associated with HRQoL at 3 and 12 months post-stroke. The patients with higher FI-LAB had lower HRQoL scores, indicating that frailty may be an important factor influencing long-term HRQoL in stroke patients.
FI-LAB could serve as a predictive tool for HRQoL in AIS patients. It may help clinicians identify high-risk frail patients early and develop personalized intervention strategies to improve post-stroke recovery and long-term quality of life.
health-related quality of life
stroke
