Hassan Bekhet A1, Ramadan Abdalla A2, M. Ismail H3, M. Genena D4, A. Osman N4, Elkhatib A5, Labib Abbas R5
1Cairo University, Faculty of Physical Therapy, Cairo, Egypt, 2Faculty of Medicine, Mansoura University, Mansoura, Egypt, 3Medical Research Group of Egypt, Alexandria, Egypt, 4Research Institute, Alexandria University, Alexandria, Egypt, 5Department of Physical Therapy, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon
Background: Breast cancer (BC) is the second most common cancer worldwide and the most frequent cancer among women with an increasing incidence in the last decade. It represents 25% of the overall cancer among women. The World Health Organization (WHO) ranked BC as the fifth most common cause of cancer mortality worldwide (522,000 deaths in 2012). The significant improvements in BC screening, diagnosis, and treatment over the past few decades led to a decline in BC-related death rate which in turn reflects a substantial increase in the number of( BC). The American Cancer Society guidelines recommended at least 150 minutes on a weekly basis for exercise practicing Several randomized controlled trials(RCTs) suggested the efficacy of aerobic exercise in reducing cancer-related fatigue among BC survivors.Moreover, aerobic physical activity was found effective in improving anthropometric measures as body weight, body composition, and VO2 peak as well as reducing inflammatory markers which improves the survival rate .
Purpose: We performed this systematic review of the literature to summarize and investigate the efficacy of aerobic exercise intervention on physical activity, quality of life, weight, inflammatory markers and sleep among breast cancer survivors by scrutinizing the published trials.
Methods: We searched PubMed, Web of knowledge, Scopus, Cochrane Central, Virtual Health Library and PEDRO databases for relevant RCTs comparing aerobic exercise with usual care among BC survivors Data were extracted and evidence was synthesized narratively.
Results: Twelve studies were included in our review. Studies reported that aerobic exercise can significantly improve the quality of life BC survivors. Moreover, aerobic exercise alleviated the symptoms of depression and anxiety. However, current evidence from the included studies showed that there was no significant benefit for aerobic exercise in terms of weight loss
Conclusion(s): Our study suggests that aerobic exercise intervention is beneficial to breast cancer survivors.
Implications: The review findings supports that aerobic exercise intervention was beneficial to BC survivors, it can improve clinical outcomes in BC survivors. It improves fatigue associated with breast cancer by improving levels of physical activity and intensity as well as quality of life. Aerobic exercise also enhances the stability of sleep among breast cancer survivors allocated to intervention group.
Keywords: Aerobic Exercise, Breast Cancer Survivors, Physical Activity
Funding acknowledgements:Funding sources: None to declare
Purpose: We performed this systematic review of the literature to summarize and investigate the efficacy of aerobic exercise intervention on physical activity, quality of life, weight, inflammatory markers and sleep among breast cancer survivors by scrutinizing the published trials.
Methods: We searched PubMed, Web of knowledge, Scopus, Cochrane Central, Virtual Health Library and PEDRO databases for relevant RCTs comparing aerobic exercise with usual care among BC survivors Data were extracted and evidence was synthesized narratively.
Results: Twelve studies were included in our review. Studies reported that aerobic exercise can significantly improve the quality of life BC survivors. Moreover, aerobic exercise alleviated the symptoms of depression and anxiety. However, current evidence from the included studies showed that there was no significant benefit for aerobic exercise in terms of weight loss
Conclusion(s): Our study suggests that aerobic exercise intervention is beneficial to breast cancer survivors.
Implications: The review findings supports that aerobic exercise intervention was beneficial to BC survivors, it can improve clinical outcomes in BC survivors. It improves fatigue associated with breast cancer by improving levels of physical activity and intensity as well as quality of life. Aerobic exercise also enhances the stability of sleep among breast cancer survivors allocated to intervention group.
Keywords: Aerobic Exercise, Breast Cancer Survivors, Physical Activity
Funding acknowledgements:Funding sources: None to declare
Topic: Oncology, HIV & palliative care; Oncology, HIV & palliative care; Disability & rehabilitation
Ethics approval required: No
Institution: Physical therapy faculty, Cairo university.
Ethics committee: Physical therapy faculty, Cairo university.
Reason not required: In general, the systematic review study is exempt from ethics approval as the study authors will be collecting and synthesizing data from previous clinical trials in which informed consent has already been obtained by the trial investigators.
All authors, affiliations and abstracts have been published as submitted.
