Baptista CRJA1, Cardoso J1, Garcia B1, Nascimento-Elias AH1, Marques Junior W2, Mattiello-Sverzut AC1
1Ribeirão Preto Medical School, University of São Paulo, Health Science Department, Ribeirão Preto, Brazil, 2Ribeirão Preto Medical School, University of São Paulo, Neuroscience and Behavioral Sciences Department, Ribeirão Preto, Brazil
Background: The center of pressure velocity (CoPV) is an indirect measure of efficiency of postural control systems. However, there are no descriptions of the behavior of VCP in the child with Charcot-Marie-Tooth neuropathy (CMT), neither this variable discriminates children with and without the disease. The use of a quantitative measure could make the evaluation of the static equilibrium more precise.
Purpose: This study aimed to compare the CoPV of children and adolescents with and without CMT, under classical conditions of static posturography.
Methods: This cross-sectional study analyzed 53 participants (24 healthy; 29 CMT) of both sexes, aged 6 to 18 years. Mass, height and base of support were obtained. CoP records were obtained with a force platform (Bertec, model FP 4060-08), sampling frequency of 100Hz, 30s per trial. Four conditions (open eyes / firm surface - OEFS, open eyes / deformable surface - OEDS, closed eyes / firm surface - CEFS, closed eyes / deformable surface - CEDS) were randomly repeated 3 times, intervals for 30s. Normalized CoPV at mediolateral (ML) and anteroposterior (AP) directions were extracted using MATLAB (R2014a) (Butterworth digital filter low pass 4th order, cutoff frequency of 7Hz). Statistical analysis used the program SPSS (version-17), applying the Friedman test (Wilcoxon post-hoc, Bonferroni) for intragroup analysis. Intergroup analysis used U-Mann Whitney test (significance level of 5%).
Results: Intragroup analysis showed an increase in CoPV according to the complexity of the task in both the Control and CMT groups. In the intergroup analysis, there was a higher CoPV-ML for the CMT group (median OEFS = 10, OEDS = 14, CEFS = 12, CEDS = 27, p 0.05) compared to Control (medians OEFS = 7; OEDS =11; CEFS =8; CEDS = 18, p 0.05). Similarly, VCoP-AP was higher in the CMT group (median OEFS= 8OEDS = 13CEFS = 9, CEDS = 24, p 0.05) when compared to Control group (medians OEFS = 5; OEDS =9; CEFS =5; CEDS = 17, p = 0.05).
Conclusion(s): The sub-optimal postural control of children and adolescents with CMT was measurable based on CoPV analysis. It is affected in both directions and expresses increased values when compared to its healthy pairs.
Implications: This suggests that static posturography, specifically the variable CoPV, may be an additional tool to be considered in the evaluation of children with CMT. However, the ability of VCp to capture changes in postural control in a longitudinal design still needs to be tested.
Keywords: Charcot Marie Tooth disease, children, static posturography
Funding acknowledgements: This research did not receive any specific funding from agencies from public, commercial, or non-profit sectors.
Purpose: This study aimed to compare the CoPV of children and adolescents with and without CMT, under classical conditions of static posturography.
Methods: This cross-sectional study analyzed 53 participants (24 healthy; 29 CMT) of both sexes, aged 6 to 18 years. Mass, height and base of support were obtained. CoP records were obtained with a force platform (Bertec, model FP 4060-08), sampling frequency of 100Hz, 30s per trial. Four conditions (open eyes / firm surface - OEFS, open eyes / deformable surface - OEDS, closed eyes / firm surface - CEFS, closed eyes / deformable surface - CEDS) were randomly repeated 3 times, intervals for 30s. Normalized CoPV at mediolateral (ML) and anteroposterior (AP) directions were extracted using MATLAB (R2014a) (Butterworth digital filter low pass 4th order, cutoff frequency of 7Hz). Statistical analysis used the program SPSS (version-17), applying the Friedman test (Wilcoxon post-hoc, Bonferroni) for intragroup analysis. Intergroup analysis used U-Mann Whitney test (significance level of 5%).
Results: Intragroup analysis showed an increase in CoPV according to the complexity of the task in both the Control and CMT groups. In the intergroup analysis, there was a higher CoPV-ML for the CMT group (median OEFS = 10, OEDS = 14, CEFS = 12, CEDS = 27, p 0.05) compared to Control (medians OEFS = 7; OEDS =11; CEFS =8; CEDS = 18, p 0.05). Similarly, VCoP-AP was higher in the CMT group (median OEFS= 8OEDS = 13CEFS = 9, CEDS = 24, p 0.05) when compared to Control group (medians OEFS = 5; OEDS =9; CEFS =5; CEDS = 17, p = 0.05).
Conclusion(s): The sub-optimal postural control of children and adolescents with CMT was measurable based on CoPV analysis. It is affected in both directions and expresses increased values when compared to its healthy pairs.
Implications: This suggests that static posturography, specifically the variable CoPV, may be an additional tool to be considered in the evaluation of children with CMT. However, the ability of VCp to capture changes in postural control in a longitudinal design still needs to be tested.
Keywords: Charcot Marie Tooth disease, children, static posturography
Funding acknowledgements: This research did not receive any specific funding from agencies from public, commercial, or non-profit sectors.
Topic: Neurology; Paediatrics
Ethics approval required: Yes
Institution: Ribeirão Preto Medical School of the University of São Paulo
Ethics committee: Medical Ethical Committee of the Clinical Hospital
Ethics number: CAAE number 37328214.9.0000.5440
All authors, affiliations and abstracts have been published as submitted.
