Kimura A1
1Gunma Paz University, Graduate School of Health Sciences, Takasaki, Japan
Background: Vascular function has been studied as a factor influencing the risk of death in stroke patients. We found that the combination of paralyzed limb muscle mass and non-REM body movement is important in research related to vascular function using artificial intelligence. A 5-year cohort study observed impaired vascular function in association with decreased body movement during sleep. One factor behind this decrease in body movement is that the association between aging and lack of sleep is not commonly evaluated. It is suspected that intermittent arousal time in stroke patients leads to maintenance of vascular function. However, it is difficult to perform an RCT to examine this hypothesis.
Purpose: The purpose of this research is to clarify the influence of sleep deprivation in stroke patients on predicted vascular function and risk of death by using Pseudo RCT and propensity scoring.
Methods: Subjects were 44 stroke survivors living in elder-care health facilities.
The 5-year study was performed between 2014 and 2018.
Method
Design: Pseudo RCT using inverse propensity score weighting in a cohort study
Method: The measured sleep data and the intermittent arousal time associated with abnormal the vascular function were investigated using ROC curves and divided into two groups with a cutoff value and propensity score by age, blood pressure, and sex as the control condition of the Pseudo RCT, weighted by this reciprocal number. We analyzed the influence of abnormal vascular function associated with intermittent wake-time duration.
A body composition meter, a vascular function measurement device, a body motion measurement device using electromagnetic waves, and an Actigraph were used. Statistical analysis was performed using a generalized linear model with IBM-SPSS and Pseudo RCT analysis using propensity scoring.
Critical values of vascular function were measured using Nihon-chorin BP230RPE device at baPWV1800cm/sec.
Results: Analysis was performed for 44 subjects. Background data included: males, 14%, females, 86% (average ± SE) body weight 47 ± 0.652 kg, height 147 ± 0.8 cm, age 83 ± 1.14 years. ROC showed intermittent arousal time of 104 minutes, with sensitivity 0.857, specificity 0.378.
Conclusion(s): Sleep deprivation in stroke patients was evaluated by using Pseudo RCT based on propensity scoring.Intermittent arousal time of more than 100 minutes with sleep deprivation more than doubled the mortality risk associated with functional vascular deterioration, compared to that associated with a longer duration.
Implications: Sleep deprivation in stroke patients was evaluated by using Pseudo RCT based on propensity scoring. Intermittent arousal time of more than 100 minutes with sleep deprivation more than doubled the mortality risk associated with functional vascular deterioration, compared to that associated with a longer duration.
Keywords: Stroke, Vascular Function, Pseudo RCT
Funding acknowledgements: JSPS KAKENHI Grant Number JP24593523
Purpose: The purpose of this research is to clarify the influence of sleep deprivation in stroke patients on predicted vascular function and risk of death by using Pseudo RCT and propensity scoring.
Methods: Subjects were 44 stroke survivors living in elder-care health facilities.
The 5-year study was performed between 2014 and 2018.
Method
Design: Pseudo RCT using inverse propensity score weighting in a cohort study
Method: The measured sleep data and the intermittent arousal time associated with abnormal the vascular function were investigated using ROC curves and divided into two groups with a cutoff value and propensity score by age, blood pressure, and sex as the control condition of the Pseudo RCT, weighted by this reciprocal number. We analyzed the influence of abnormal vascular function associated with intermittent wake-time duration.
A body composition meter, a vascular function measurement device, a body motion measurement device using electromagnetic waves, and an Actigraph were used. Statistical analysis was performed using a generalized linear model with IBM-SPSS and Pseudo RCT analysis using propensity scoring.
Critical values of vascular function were measured using Nihon-chorin BP230RPE device at baPWV1800cm/sec.
Results: Analysis was performed for 44 subjects. Background data included: males, 14%, females, 86% (average ± SE) body weight 47 ± 0.652 kg, height 147 ± 0.8 cm, age 83 ± 1.14 years. ROC showed intermittent arousal time of 104 minutes, with sensitivity 0.857, specificity 0.378.
Conclusion(s): Sleep deprivation in stroke patients was evaluated by using Pseudo RCT based on propensity scoring.Intermittent arousal time of more than 100 minutes with sleep deprivation more than doubled the mortality risk associated with functional vascular deterioration, compared to that associated with a longer duration.
Implications: Sleep deprivation in stroke patients was evaluated by using Pseudo RCT based on propensity scoring. Intermittent arousal time of more than 100 minutes with sleep deprivation more than doubled the mortality risk associated with functional vascular deterioration, compared to that associated with a longer duration.
Keywords: Stroke, Vascular Function, Pseudo RCT
Funding acknowledgements: JSPS KAKENHI Grant Number JP24593523
Topic: Neurology: stroke; Health promotion & wellbeing/healthy ageing; Non-communicable diseases (NCDs) & risk factors
Ethics approval required: Yes
Institution: IRB in Gunma Paz University
Ethics committee: IRB in Gunma Paz University
Ethics number: 7598
All authors, affiliations and abstracts have been published as submitted.
