EFFECTS OF EXERCISE-BASED MANAGEMENT ON MOTOR SYMPTOMS IN PARKINSON\'S DISEASE - A META-ANALYSIS

S. Farooqui^1,1, F. Hussain¹, B. Hassan¹, I. Ali Khan¹, A. Khan¹

¹Ziauddin University, Karachi, Pakistan

Background: Parkinson's disease (PD) is the second-most-common neurological illness after Alzheimer's disease. According to research, medication alone can give palliative alleviation; however, freezing of gait and balance can be treated with physical therapy treatment.

Purpose: This meta-analysis aims to bridge gaps about exercise-based therapy's impact on balance and freezing of gait (FOG) in individuals with Parkinson's disease.

Methods: The current meta-analysis was performed in accordance with the guidelines of PRISMA and registered in the international database of PROSPERO (register number: CRD42021284371).Google Scholar, CINHAL, Medline, PubMed, and PEDro were searched for 2016-2021 citations using the "PIOD" paradigm. RevMan analyzed data. Pooled effect size mean and SD were analyzed using a fixed and random effects model. The I² statistic was used to calculate the heterogeneity. Cochrane examined RCTs for bias.

Results: A total 21 trials were included in this review, with SMD=0.62 and P=0.0002 utilizing BBS, pooled analysis revealed statistically significant impacts on exercise-based management in the experimental group. With SMD=0.87 and P<0.00001 using Mini-BESTest, the pooled analysis revealed that exercise-based management was also effective on balance in the experimental group. The fixed effect model of FOG in terms of SMD was used to draw the pooled effects of FOG in terms of SMD and FOG in terms of SMD (0.21; 95 percent CI -0.01 to 0.44; P=0.06).

Conclusions: This review concluded that various physiotherapy treatments, such as exergaming, gamepad systems, virtual reality, gait exercises, and core training, are beneficial for the rehabilitation of balance and FOG in patients with Parkinson's disease aged 31 and older who are in stages I-IV.

Implications: This analysis of RCTs (2016-2021) employing valid and trustworthy instruments such as the BBS, TUG, Mini-BESTest, FOG-Q, and nFOG-Q has the benefit of being high-quality research in the hierarchy. It was extensive study with stringent selection criteria and a thorough data extraction strategy.

Funding acknowledgements: N/A

Keywords:
Parkinson's Disease
Balance
Freezing of Gait

Topics:
Neurology: Parkinson's disease
Health promotion & wellbeing/healthy ageing/physical activity

Did this work require ethics approval? No

Reason: IT IS A META ANALYSIS REGISTERED IN PROSPERO