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Fioritto A1, Albuquerque V1, Almeida L1, Oliveira C1, Malaguti C1
1Federal University of Juiz de Fora, Juiz de Fora, Brazil
Background: Patients undergoing hematopoietic stem cell transplantation (HSCT) are highly complex due to the frequent occurrence of complications related to the disease itself and treatment side-effects. Even when successful, an overall deterioration in health status is reported in these patients including reductions in functional capacity, peripheral muscle strength and health related quality life (HRQoL), these are important factors related to mortality in this population. Successful treatment is closely related to multidisciplinary rehabilitation, which aims to promote functional independence and to improve patients' HRQoL following HSCT.
Purpose: To evaluate whether a novel individualized exercise training program for hospitalized patients undergoing HSCT is feasible and safe and whether it would improve functional capacity, muscle strength and HRQoL.
Methods: This was a prospective, single group, feasibility intervention study, enrolling 26 participants (58% female), aged 40±15 (mean±SD) years were included patients electively hospitalized for HSCT who were admitted to the bone marrow transplant unit. Participants performed the individualized in-hospital exercise training program on a daily basis during their hospital admission. The exercise training program was performed once a day for 20 to 40 minutes and included a warm-up period, moderate-intensity aerobic exercise, muscle strengthening exercise and cool-down activities. The primary outcomes were feasibility (consent rate, attrition rate and exercise adherence) and safety of the exercise program. Secondary outcomes included six minutes step test, sit-to-stand test, upper limb muscle strength and HRQoL were evaluated at baseline (on admission to hospital) and prior to hospital discharge.
Results: The mean (SD) hospital stay was 23±7 days. The intervention´s feasibility was demonstrated by 100% consent rate, 12% attrition rate and 86% exercise adherence rate. No adverse events occurred. From baseline to follow-up, significant differences were observed in functional capacity (p = 0.03) and upper limb muscle strength (p = 0.01). There was no change in HRQoL.
Conclusion(s): An individualized exercise training program based on clinical, hemodynamic and hematological parameters is feasible and safe for hospitalized patients undergoing HSCT. Improvements in functional capacity and muscle strength were observed over time. Therefore this intervention warrants further investigation in a randomized controlled trial.
Implications: The individualized in-hospital exercise training program guided by daily clinical, hemodynamic and hematologic parameters is feasible and safe for patients undergoing HSTC. The individualized in-hospital exercise training program can improve functional capacity and muscle strength from hospital admission to discharge in patient undergoing HSCT.
Keywords: hematopoietic stem cell transplantation, exercise training, feasibility
Funding acknowledgements: Capes, CNPq and Fapemig
This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001
Purpose: To evaluate whether a novel individualized exercise training program for hospitalized patients undergoing HSCT is feasible and safe and whether it would improve functional capacity, muscle strength and HRQoL.
Methods: This was a prospective, single group, feasibility intervention study, enrolling 26 participants (58% female), aged 40±15 (mean±SD) years were included patients electively hospitalized for HSCT who were admitted to the bone marrow transplant unit. Participants performed the individualized in-hospital exercise training program on a daily basis during their hospital admission. The exercise training program was performed once a day for 20 to 40 minutes and included a warm-up period, moderate-intensity aerobic exercise, muscle strengthening exercise and cool-down activities. The primary outcomes were feasibility (consent rate, attrition rate and exercise adherence) and safety of the exercise program. Secondary outcomes included six minutes step test, sit-to-stand test, upper limb muscle strength and HRQoL were evaluated at baseline (on admission to hospital) and prior to hospital discharge.
Results: The mean (SD) hospital stay was 23±7 days. The intervention´s feasibility was demonstrated by 100% consent rate, 12% attrition rate and 86% exercise adherence rate. No adverse events occurred. From baseline to follow-up, significant differences were observed in functional capacity (p = 0.03) and upper limb muscle strength (p = 0.01). There was no change in HRQoL.
Conclusion(s): An individualized exercise training program based on clinical, hemodynamic and hematological parameters is feasible and safe for hospitalized patients undergoing HSCT. Improvements in functional capacity and muscle strength were observed over time. Therefore this intervention warrants further investigation in a randomized controlled trial.
Implications: The individualized in-hospital exercise training program guided by daily clinical, hemodynamic and hematologic parameters is feasible and safe for patients undergoing HSTC. The individualized in-hospital exercise training program can improve functional capacity and muscle strength from hospital admission to discharge in patient undergoing HSCT.
Keywords: hematopoietic stem cell transplantation, exercise training, feasibility
Funding acknowledgements: Capes, CNPq and Fapemig
This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001
Topic: Oncology, HIV & palliative care; Cardiorespiratory
Ethics approval required: Yes
Institution: Federal University of Juiz de Fora
Ethics committee: Comitê de ética do Hospital Universitário da UFJF
Ethics number: 2030132
All authors, affiliations and abstracts have been published as submitted.
