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Bansi J1, Kool J2, Kessselring J3, Bloch W4, Langdon D5, Dalgas U6, Zimmer P4
1Kliniken-Valens, Physiotherapy, Valens, Switzerland, 2Kliniken Valens / Consultant PT, Physiotherapy, Valens, Switzerland, 3Kliniken-Valens, Neurology, Valens, Switzerland, 4German Sportuniversity Cologne, Molecular and Celluar Sport Medicine, Cologne, Germany, 5Royal Holloway University of London, Egham, United Kingdom, 6Aarhus University, Department of Public Health Section Sport Science, Aarhus, Denmark
Background: Regular exercise is known to induce physiological, structural and functional adaptations to the central nervous system. Moreover exercise induces alterations in levels of matrix metalloproteinases that are known to play a crucial role in blood-brain barrier function and impacts on MS pathogenesis are suggested.
Purpose: This study investigates the influences of a high-intensive aerobic exercise programme (HIT-group) on cognitive performance in persons with multiple sclerosis compared to the standard exercise programme (control Training, CT Group).
Methods: 60 persons with MS (Expanded Disabiliy Staus Scale, EDSS: 1.0-6.5) were randomized to a HIT group (3x per week for 20 minutes including five 3-minute exercise intervals at 85% of peak oxygen uptake (VO2-peak)) or a CT group (continous training 5x per week for 30 minutes per session at 70% of VO2-peak). Cognitive performance was assessed using the Brief International Cognitive Assessment for MS (BICAMS) at entry (T0) and discharge (T1). Furthermore VO2-peak, brain-derived neurotrophic factor, serotonin and matrix metalloproteinases (MMP)-2 and-9 were measured.
Results: Compared to the CT, HIT significantly improved verbal memory. Significant improvements over time in executive functions were found in both Groups. Secondary outcomes indicated sigificant improvements inVO2-peak and significant reductions in MMP-2 in the HIT Group only.
Conclusion(s): HIT represents a promising therapeutical strategy for improving verbal memory and physical fitness in persons with multiple sclerosis. Hit programmes are a time efficient supportive strategy Further Research is needed to determine the Impact of exercise on biomarkers in MS.
Implications: Hit programmes are a time efficient supportive strategy that can easily be integrated into an MS rehabilitytive setiing.
Keywords: Exercise, Cognition, Multiple sclerosis
Funding acknowledgements: This study was funded by the Swiss multiple Sclerosis Society
Purpose: This study investigates the influences of a high-intensive aerobic exercise programme (HIT-group) on cognitive performance in persons with multiple sclerosis compared to the standard exercise programme (control Training, CT Group).
Methods: 60 persons with MS (Expanded Disabiliy Staus Scale, EDSS: 1.0-6.5) were randomized to a HIT group (3x per week for 20 minutes including five 3-minute exercise intervals at 85% of peak oxygen uptake (VO2-peak)) or a CT group (continous training 5x per week for 30 minutes per session at 70% of VO2-peak). Cognitive performance was assessed using the Brief International Cognitive Assessment for MS (BICAMS) at entry (T0) and discharge (T1). Furthermore VO2-peak, brain-derived neurotrophic factor, serotonin and matrix metalloproteinases (MMP)-2 and-9 were measured.
Results: Compared to the CT, HIT significantly improved verbal memory. Significant improvements over time in executive functions were found in both Groups. Secondary outcomes indicated sigificant improvements inVO2-peak and significant reductions in MMP-2 in the HIT Group only.
Conclusion(s): HIT represents a promising therapeutical strategy for improving verbal memory and physical fitness in persons with multiple sclerosis. Hit programmes are a time efficient supportive strategy Further Research is needed to determine the Impact of exercise on biomarkers in MS.
Implications: Hit programmes are a time efficient supportive strategy that can easily be integrated into an MS rehabilitytive setiing.
Keywords: Exercise, Cognition, Multiple sclerosis
Funding acknowledgements: This study was funded by the Swiss multiple Sclerosis Society
Topic: Neurology; Disability & rehabilitation; Cardiorespiratory
Ethics approval required: Yes
Institution: Kantonsspital St. Gallen
Ethics committee: EKOS
Ethics number: 15/090
All authors, affiliations and abstracts have been published as submitted.
