Estrada Bonilla YC1,2, Russo TL3
1Saint Thomas University, Physica Culture, Sports and Recreation Program, Bogotá, Colombia, 2Colombian School of Rehabilitation, Physiotherapy Department, Bogotá, Colombia, 3Federal University of Sao Carlos, Physiotherapy Department, São Carlos, Brazil
Background: Some of most common Non Communicable Chronic Diseases - NCCD, such as Stroke and Diabetes Mellitus coexist in majority in the same person, generating complications in functional independence of individuals. Several studies show that one of motor tasks that are compromised are reaching tasks. However, until now the influence that the coexistence of DM together with stroke episode generate in motor performance of the upper limbs when carrying out common motor tasks such as reaching task is unknown.
Purpose: Describe how the coexistence of Type I Diabetes Mellitus with stroke can negatively influence motor performance of the upper limbs, in execution of reaching task in animal models of the two diseases.
Methods: 24 three-month-old Wistar rats were divided into 4 groups: 1. Control group; 2. DM Group: rats with type 1 DM induction; 3. Group CI - Cerebral Ischemia: rats with cerebral ischemia; 4. DM + CI group: rats with DM and cerebral ischemia induction. Experiment was executed in 6 phases. In stage 1, all animals went through habituation process to the training box of reaching task. In stage 2, all animals pass to determination of dominance of upper limb. In Stage 3, once the dominance of the upper limb of the animal is known, it goes to training reaching task. In stage 4, evaluation of motor performance of the upper limbs is performed in the reaching task. Subsequently, induction of DM or the sham thereof was carried out, applying STZ induction. In stage 5, two weeks after having made the first evaluation of motor performance, a second evaluation of motor performance is performed to subsequently perform induction or sham induction of cerebral ischemia, with sterotaxic surgery and application of Endothelin 1. In stage 6, a third assessment of motor performance was performed, four days after enhancing the induction of cerebral ischemia. In stage 7, a fourth evaluation of motor performance (final) is carried out. Statistical analysis was made with repeated measurement ANOVA.
Results: In intergroup comparison, individuals in CI group had the most significant drop in motor performance in third moment of the reaching task test, compared with other groups (p= 0.01). In the same way, these same subjects (CI group) presented highest recovery of motor performance in fourth moment of reaching task test, when compared with the other groups at that same moment (p= 0.01). In intragroup comparison, individuals of DM + IC group had worst percentage of the same in fourth moment of evaluation of the motor performance, when compared with the performance obtained in the other three moments.
Conclusion(s): Coexistence of DM with stroke could explain the inability of an individual to recover his motor performance in upper limbs, when the same capacity is compared with the presence of only one of the two diseases.
Implications: There is still no clarity about the conditions that can be established in the motor performance of upper limbs due to the coexistence of two high-prevalence NCCD, which are so common in patients who arrive today. to our rehabilitation services.
Keywords: Motor Performance, Reaching task, Non Comunicable Chronic diseases
Funding acknowledgements: Sao Paulo Research Foundation - FAPESP, Federal University of São Carlos, Colfuturo-Colciencias and Saint Thomas University
Purpose: Describe how the coexistence of Type I Diabetes Mellitus with stroke can negatively influence motor performance of the upper limbs, in execution of reaching task in animal models of the two diseases.
Methods: 24 three-month-old Wistar rats were divided into 4 groups: 1. Control group; 2. DM Group: rats with type 1 DM induction; 3. Group CI - Cerebral Ischemia: rats with cerebral ischemia; 4. DM + CI group: rats with DM and cerebral ischemia induction. Experiment was executed in 6 phases. In stage 1, all animals went through habituation process to the training box of reaching task. In stage 2, all animals pass to determination of dominance of upper limb. In Stage 3, once the dominance of the upper limb of the animal is known, it goes to training reaching task. In stage 4, evaluation of motor performance of the upper limbs is performed in the reaching task. Subsequently, induction of DM or the sham thereof was carried out, applying STZ induction. In stage 5, two weeks after having made the first evaluation of motor performance, a second evaluation of motor performance is performed to subsequently perform induction or sham induction of cerebral ischemia, with sterotaxic surgery and application of Endothelin 1. In stage 6, a third assessment of motor performance was performed, four days after enhancing the induction of cerebral ischemia. In stage 7, a fourth evaluation of motor performance (final) is carried out. Statistical analysis was made with repeated measurement ANOVA.
Results: In intergroup comparison, individuals in CI group had the most significant drop in motor performance in third moment of the reaching task test, compared with other groups (p= 0.01). In the same way, these same subjects (CI group) presented highest recovery of motor performance in fourth moment of reaching task test, when compared with the other groups at that same moment (p= 0.01). In intragroup comparison, individuals of DM + IC group had worst percentage of the same in fourth moment of evaluation of the motor performance, when compared with the performance obtained in the other three moments.
Conclusion(s): Coexistence of DM with stroke could explain the inability of an individual to recover his motor performance in upper limbs, when the same capacity is compared with the presence of only one of the two diseases.
Implications: There is still no clarity about the conditions that can be established in the motor performance of upper limbs due to the coexistence of two high-prevalence NCCD, which are so common in patients who arrive today. to our rehabilitation services.
Keywords: Motor Performance, Reaching task, Non Comunicable Chronic diseases
Funding acknowledgements: Sao Paulo Research Foundation - FAPESP, Federal University of São Carlos, Colfuturo-Colciencias and Saint Thomas University
Topic: Non-communicable diseases (NCDs) & risk factors; Musculoskeletal: upper limb; Neurology
Ethics approval required: Yes
Institution: Federal University Of São Carlos
Ethics committee: CONCEA
Ethics number: 4364131216
All authors, affiliations and abstracts have been published as submitted.
