Hellweg S1, Häni N2, Manettas A2, de Bruin ED3,4, Brugger P5, Knols RH6
1Rehaklinik Bellikon, Department of Neurological Rehabilitation, Bellikon, Switzerland, 2University Hospital Zurich, Physiotherapy & Occupational Therapy PEU, Zurich, Switzerland, 3Institute of Human Movement Sciences and Sport, ETH-Zurich, Department of Health Sciences and Technology (D-HEST), Zurich, Switzerland, 4Care Sciences and Society, Karolinska Institute, Division of Physiotherapy, Department of Neurobiology, Stockholm, Sweden, 5University Hospital Zurich, Department of Neurology, Neuropsychology Unit, Zurich, Switzerland, 6University Hospital Zurich, Physiotherapy Occupational Research Centre, Zurich, Switzerland
Background: The Template for Intervention Description and Replication (TIDieR) checklist allows interventions descriptions assessment for their replicability in research and clinical practice. A systematic review with the use of the 12-items TiDieR checklist assessing the minuteness of details of interventions for early mobilization in patients with acquired brain injury (ABI) during acute care is currently unavailable.
Purpose: To summarize the current literature and to report the minuteness of details of interventions for early mobilization in patients with ABI during acute care as well as to evaluate the methodological quality of the included studies.
Methods: A systematic search for early mobilization interventions in patients with ABI during acute care was conducted in the databases Medline-Ovid, Embase, CINAHL, PsychINFO and Cochrane Library. Two independent reviewers assessed the description of the interventions with the use of the TIDieR checklist. Methodological quality of the studies was assessed with the Downs und Black Checklist for the clinical studies and Risk of Bias Checklist for the RCTs.
Results: The literature search yielded 9 studies meeting the inclusion criteria. Two studies were RCT's and 7 were non randomized trials. The review of intervention replicability using the TIDieR checklist showed that 3 studies had a low (0-4 items covered), 5 a moderate (5-8 items covered), and one study (10 Items of 12 were well covered) a high coverage of the 12 TIDieR checklist items. The methodological quality of both RCT´s was moderate with a PEDro score of 6/10. One RCT had a medium (3/7) and one a low (5/7) risk of systematic bias. Seven non-RCT´s received a score for methodological quality of 10.71 of 19 points (median 10, Downs and Black checklist)
Conclusion(s): This systematic review provides insight into the replicability of early mobilization in patients with acquired brain injury in acute care. Findings underline the incompleteness and impreciseness of description of intervention in most of the published studies, which prevents their replicability. Furthermore, the methodological quality of the included RCT's was moderate
Implications: Consistent use of the TIDieR checklist when planning clinical trials is recommended with the aim to increase the minuteness of details of interventions for early mobilization in patients with ABI. This will aid the replicability of successful interventions in clinical practice and allow performance of confirmatory studies in acute care.
Keywords: Early Mobilization, acquired brain injury, TIDieR checklist
Funding acknowledgements: no funding
Purpose: To summarize the current literature and to report the minuteness of details of interventions for early mobilization in patients with ABI during acute care as well as to evaluate the methodological quality of the included studies.
Methods: A systematic search for early mobilization interventions in patients with ABI during acute care was conducted in the databases Medline-Ovid, Embase, CINAHL, PsychINFO and Cochrane Library. Two independent reviewers assessed the description of the interventions with the use of the TIDieR checklist. Methodological quality of the studies was assessed with the Downs und Black Checklist for the clinical studies and Risk of Bias Checklist for the RCTs.
Results: The literature search yielded 9 studies meeting the inclusion criteria. Two studies were RCT's and 7 were non randomized trials. The review of intervention replicability using the TIDieR checklist showed that 3 studies had a low (0-4 items covered), 5 a moderate (5-8 items covered), and one study (10 Items of 12 were well covered) a high coverage of the 12 TIDieR checklist items. The methodological quality of both RCT´s was moderate with a PEDro score of 6/10. One RCT had a medium (3/7) and one a low (5/7) risk of systematic bias. Seven non-RCT´s received a score for methodological quality of 10.71 of 19 points (median 10, Downs and Black checklist)
Conclusion(s): This systematic review provides insight into the replicability of early mobilization in patients with acquired brain injury in acute care. Findings underline the incompleteness and impreciseness of description of intervention in most of the published studies, which prevents their replicability. Furthermore, the methodological quality of the included RCT's was moderate
Implications: Consistent use of the TIDieR checklist when planning clinical trials is recommended with the aim to increase the minuteness of details of interventions for early mobilization in patients with ABI. This will aid the replicability of successful interventions in clinical practice and allow performance of confirmatory studies in acute care.
Keywords: Early Mobilization, acquired brain injury, TIDieR checklist
Funding acknowledgements: no funding
Topic: Neurology; Disability & rehabilitation; Non-communicable diseases (NCDs) & risk factors
Ethics approval required: No
Institution: University Hospital Zurich
Ethics committee: University Hospital Zurich
Reason not required: no intervention, systematic review
All authors, affiliations and abstracts have been published as submitted.
